Aberrant GATA2 epigenetic dysregulation induces a GATA2/GATA6 switch in human gastric cancer

Volume: 37, Issue: 8, Pages: 993 - 1004
Published: Nov 6, 2017
Abstract
Six GATA transcription factors play important roles in eukaryotic development. Among these, GATA2, an essential factor for the hematopoietic cell lineage, exhibits low expression in human gastric tissues, whereas GATA6, which is crucial for gastrointestinal development and differentiation, is frequently amplified and/or overexpressed in human gastric cancer. Interestingly, we found that GATA6 was overexpressed in human gastric cancer cells only...
Paper Details
Title
Aberrant GATA2 epigenetic dysregulation induces a GATA2/GATA6 switch in human gastric cancer
Published Date
Nov 6, 2017
Journal
Volume
37
Issue
8
Pages
993 - 1004
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