A neoantigen fitness model predicts tumour response to checkpoint blockade immunotherapy
Abstract
Checkpoint blockade immunotherapies enable the host immune system to recognize and destroy tumour cells. Their clinical activity has been correlated with activated T-cell recognition of neoantigens, which are tumour-specific, mutated peptides presented on the surface of cancer cells. Here we present a fitness model for tumours based on immune interactions of neoantigens that predicts response to immunotherapy. Two main factors determine...
Paper Details
Title
A neoantigen fitness model predicts tumour response to checkpoint blockade immunotherapy
Published Date
Nov 1, 2017
Journal
Volume
551
Issue
7681
Pages
517 - 520
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