Optimal Cut-Off Value for Locus Coeruleus-to-Pons Intensity Ratio as Clinical Biomarker for Alzheimer’s Disease: A Pilot Study

Studies using neuromelanin-sensitive-MRI have established the locus coeruleus (LC)-to-pons intensity ratio as a biomarker for diagnosis of Parkinson's and Alzheimer's diseases. More detailed analysis is needed for exploiting the highest clinical potential of this technique.The aim is to determine the location of the highest LC-to-pons ratio within the LC and develop an easy-to-use tool for clinical application.Ten patients diagnosed with various...