The Immunogenicity of Biologic Therapies

Pages: 37 - 48
Published: Nov 7, 2017
Abstract
Virtually all therapeutic proteins (biologics) elicit an immune response with the consequent production of anti-drug antibodies (ADA). The majority of ADA to therapeutic monoclonal antibodies (mAbs) are directed against the antigen-binding site of the therapeutic mAb, and hence are neutralizing. This nature of the ADA response explains why fully human antibodies can still be highly immunogenic. The detection of ADA is technically challenging and...
Paper Details
Title
The Immunogenicity of Biologic Therapies
Published Date
Nov 7, 2017
Pages
37 - 48
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