A single institution twenty-year experience of recurrent or metastatic epithelial non glandular sinonasal cancer

Background: Sinonasal cancers (SC) are rare and heterogeneous tumors, whose natural history depends on histology and stage. Clinical trials (ClinicalTrials.gov: NCT02099175, NCT02099188. AIOM: 2013-000075-33) are ongoing to evaluate the role of multimodal therapies (MMT, consisting in induction chemotherapy -iCT- followed by locoregional therapy) as upfront treatment. Few data about the outcome of relapsed and metastatic disease are available....