Gene-expression profiles of primary and metastatic lesions in head and neck squamous cell carcinoma

Background: Mechanisms of tumour spread and the deregulation level exisisting in distant metastatic lesions, in comparison with primary disease, are not fully understood in head and neck squamous cell carcinoma (HNSCC). We would test at molecular level the hypothesis that the development of the metastatic disease is linked to the biologic characteristics of the primary tumour more than to the degree of regional nodes involvement Matherials and...