Phenotypic characterization of P23H and S334ter rhodopsin transgenic rat models of inherited retinal degeneration
Abstract
We produced 8 lines of transgenic (Tg) rats expressing one of two different rhodopsin mutations in albino Sprague-Dawley (SD) rats. Three lines were generated with a proline to histidine substitution at codon 23 (P23H), the most common autosomal dominant form of retinitis pigmentosa in the United States. Five lines were generated with a termination codon at position 334 (S334ter), resulting in a C-terminal truncated opsin protein lacking the...
Paper Details
Title
Phenotypic characterization of P23H and S334ter rhodopsin transgenic rat models of inherited retinal degeneration
Published Date
Feb 1, 2018
Journal
Volume
167
Pages
56 - 90
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