Extending the Structural View of Class B GPCRs
Abstract
Methodological developments in X-ray crystallography and cryo-electron microscopy have enabled the determination of the first full-length and G protein-coupled structures of class B G protein-coupled receptors (GPCRs). Structural comparison of different class B GPCR–ligand complexes provides insights into the molecular mechanisms of receptor activation, including: (i) ligand-induced conformational changes of extracellular and transmembrane...
Paper Details
Title
Extending the Structural View of Class B GPCRs
Published Date
Dec 1, 2017
Volume
42
Issue
12
Pages
946 - 960
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