ADAMTS‐13 and von Willebrand factor: a dynamic duo

Volume: 16, Issue: 1, Pages: 6 - 18
Published: Jan 1, 2018
Abstract
von Willebrand factor (VWF) is a key player in hemostasis, acting as a carrier for factor VIII and capturing platelets at sites of vascular damage. To capture platelets, it must undergo conformational changes, both within its A1 domain and at the macromolecular level through A2 domain unfolding. Its size and this function are regulated by the metalloproteinase ADAMTS-13. Recently, it has been shown that ADAMTS-13 undergoes a conformational...
Paper Details
Title
ADAMTS‐13 and von Willebrand factor: a dynamic duo
Published Date
Jan 1, 2018
Volume
16
Issue
1
Pages
6 - 18
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