Correlation between Thyroid Stimulating Hormone and Renal Function in Euthyroid Residents of Japan: Results from the Kyushu and Okinawa Population Study (KOPS)

Published on Oct 18, 2017in Journal of Atherosclerosis and Thrombosis4.928
· DOI :10.5551/JAT.41251
Yuki Tanaka10
Estimated H-index: 10
(Kyushu University),
Norihiro Furusyo41
Estimated H-index: 41
(Kyushu University)
+ 5 AuthorsJun Hayashi56
Estimated H-index: 56
AIM: The present large-scale Japanese population study was performed to evaluate the relation between the serum thyroid stimulating hormone (TSH) level and renal function. METHODS: Out of 1,374 residents who participated in a free public physical examination between 2010 and 2011, we evaluated the data of 888 participants for whom the serum TSH level and estimated glomerular filtration rate (eGFR) were successfully measured. The participants were categorized into three groups based on TSH levels (normal TSH, ≤2.4; high-normal TSH, 2.5-4.4; and subclinical hypothyroid, ≥4.5 μIU/mL). Multiple linear regression analysis adjusted for cardiovascular risk factors was performed to determine the relationship between serum TSH level and renal function. RESULTS: The mean±SD TSH level was 2.0±1.4 μIU/mL, and 75.9% (n=674) of the participants had normal, 17.9% (n=159) had high-normal, and 6.2% (n=55) had subclinical hypothyroid TSH levels. The mean eGFR significantly decreased with increased TSH levels (normal TSH, 79.3±14.1; high-normal TSH, 77.4±13.0; and subclinical hypothyroid, 72.3±12.2 mL/min/1.73 m2: P for trend <0.01). Multiple linear regression analysis extracted log-transformed TSH level as an independent factor correlated with eGFR in the high-normal TSH group (beta=-0.18, P=0.02). CONCLUSIONS: Our findings demonstrated a significant correlation between serum TSH levels and eGFR in high-normal TSH participants. In healthy individuals, high-normal TSH levels indicate increased the risk of chronic kidney disease.
#1Muhammad Aziz (Benedictine University)H-Index: 7
Last. Khurram NasirH-Index: 77
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AIM: Research shows that subclinical hypothyroidism (SCH) is related to an increased carotid intima-media thickness (CIMT), a surrogate marker of subclinical cardiovascular disease (CVD). It is controversial whether or not SCH should be treated to reduce CVD morbidity and mortality. This meta-analysis aimed to determine whether SCH is associated with an increase in CIMT as compared to Euthyroidism (EU) and whether thyroxin (T4) treatment in SCH can reverse the change in CIMT. METHODS: Two indepe...
#1É.J.F. Peixoto de Miranda (USP: University of São Paulo)H-Index: 4
#2Márcio Sommer Bittencourt (USP: University of São Paulo)H-Index: 28
Last. Isabela M. Benseñor (USP: University of São Paulo)H-Index: 85
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Abstract Background and aim Although subclinical hypothyroidism (SCH) is associated with cardiovascular risk, there is scarce data about subclinical atherosclerosis in subjects with SCH. We aimed to analyze the association between SCH and carotid intima-media thickness (IMT) using baseline data from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Methods and Results We included subjects with normal thyroid function (TSH: 0.4–4.0 mIU/l, and normal free thyroxine (FT4): 0.8–1.9 ng/...
Both hyperthyroidism and hypothyroidism affect the cardiovascular system. Hypothyroidism is known to be associated with enhanced atherosclerosis and ischemic heart diseases. The accelerated atherosclerosis in the hypothyroid state has been traditionally ascribed to atherogenic lipid profile, diastolic hypertension, and impaired endothelial function. However, recent studies indicate that thyroid hormone has direct anti-atherosclerotic effects, such as production of nitric oxide and suppression of...
#1Yulin Zhou (SJTU: Shanghai Jiao Tong University)H-Index: 8
#2Liebin Zhao (SJTU: Shanghai Jiao Tong University)H-Index: 11
Last. Yufang Bi (SJTU: Shanghai Jiao Tong University)H-Index: 40
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Increased carotid artery intima media thickness (C-IMT) is an early feature of atherosclerosis. It has been reported to be altered in patients with thyroid dysfunction, and the evidence is still controversial. The present study aimed to explore the relationship between C-IMT and possible variations in thyroid function in Chinese adults aged 40 years and above.A community-based cross-sectional study was conducted among 2276 non-diabetic participants. Serum free triiodothyronine (FT3), free thyrox...
#1Szu-Chun Hung (TCU: Tzu Chi University)H-Index: 22
#2Yi-Shin Lai (NYMU: National Yang-Ming University)H-Index: 1
Last. Der-Cherng Tarng (Taipei Veterans General Hospital)H-Index: 25
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understood. Methods and Results-—A prospective cohort of 338 patients with stage 3 to 5 CKD was followed for a median of 2.1 years. The study participants were stratified by the presence or absence of volume overload, defined as an overhydration index assessed by bioimpedance spectroscopy exceeding 7%, the 90th percentile for the healthy population. The primary outcome was the composite of estimated glomerular filtration rate decline ≥50% or end-stage renal disease. The secondary outcome include...
#1Motohiro Shimizu (Kyushu University)H-Index: 16
#2Norihiro Furusyo (Kyushu University)H-Index: 41
Last. Jun Hayashi (Kyushu University)H-Index: 56
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Abstract Objective : To examine whether or not subclinical atherosclerosis independently predicts the incidence of chronic kidney disease (CKD) in the Japanese general population. Methods : This study is part of the Kyushu and Okinawa Population Study (KOPS), a survey of vascular events associated with lifestyle-related diseases. Participants who attended both baseline (2004–2007) and follow-up (2009–2012) examinations were eligible. The common carotid intima-media thickness (IMT) was assessed f...
#1Altan OnatH-Index: 54
#2Mesut Aydin (Dicle University)H-Index: 16
Last. Evin Ademoglu (Istanbul University)H-Index: 21
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Whether euthyroid status affects cardiovascular disease risk is unclear. We aimed to investigate whether serum thyroid-stimulating hormone (TSH) levels within the normal range are related to the risk of coronary heart disease (CHD). In participants of the Turkish Adult Risk Factor Study (mean age 52.7 ± 11.5), in whom TSH was measured in the 2004/05 survey, cross-sectional and longitudinal analyses were performed. Subjects with TSH concentrations 4.2 mIU/L were excluded to ensure euthyroid statu...
#1Yiyi Zhang (Johns Hopkins University)H-Index: 30
#2Yoosoo Chang (SKKU: Sungkyunkwan University)H-Index: 49
Last. Eliseo Guallar (Johns Hopkins University)H-Index: 99
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Background: Overt and subclinical hypothyroidism are associated with higher levels of serum creatinine and with increased risk of chronic kidney disease (CKD). The prospective association between thyroid hormones and kidney function in euthyroid individuals, however, is largely unexplored. Methods: We conducted a prospective cohort study in 104633 South Korean men and women who were free of CKD and proteinuria at baseline and had normal thyroid hormone levels and no history of thyroid disease or...
#1Mohamed Mohamedali (Penn State Milton S. Hershey Medical Center)H-Index: 1
#2Srikanth Reddy Maddika (Penn State Milton S. Hershey Medical Center)H-Index: 1
Last. Pramil Cheriyath (Penn State Milton S. Hershey Medical Center)H-Index: 1
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Thyroid hormones play a very important role regulating metabolism, development, protein synthesis, and influencing other hormone functions. The two main hormones produced by the thyroid are triiodothyronine (T3) and thyroxine (T4). These hormones can also have significant impact on kidney disease so it is important to consider the physiological association of thyroid dysfunction in relation to chronic kidney disease (CKD). CKD has been known to affect the pituitary-thyroid axis and the periphera...
#1Norihiro Furusyo (Kyushu University)H-Index: 41
#2Masumi Ai (Tufts University)H-Index: 25
Last. Jun Hayashi (Kyushu University)H-Index: 56
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Abstract Aim This epidemiological study was done to generate normal ranges for the cholesterol and triglyceride levels in serum lipoprotein subclasses isolated from healthy adults based on gender and menopausal status. Methods Cholesterol and triglyceride levels in 20 lipoprotein subclasses as separated by high performance liquid chromatography were measured in serum obtained from 825 fasting healthy subjects (267 men, 558 women). Results For serum cholesterol, 13.7% was found in very low densit...
Cited By1
#1Sijue Yang (PRC: China Medical University (PRC))
#2Shuiqing Lai (Peking Union Medical College)
Last. Haixia Guan (Southern Medical University)H-Index: 1
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BACKGROUND Previous studies have reported a negative relationship between thyroid-stimulating hormone (TSH) and renal function in euthyroid individuals, but others have found that higher free thyroxine (FT4) was associated with an increased risk of chronic kidney disease. This study was designed to analyze the relationship between thyroid and renal function from a new perspective of sensitivity to thyroid hormone. METHODS This retrospective study included 2831 euthyroid individuals who underwent...
#1Yuji Shimizu (Nagasaki University)H-Index: 26
#2Yuko Nabeshima-Kimura (Fukushima Medical University)H-Index: 2
Last. Naomi Hayashida (Nagasaki University)H-Index: 19
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BACKGROUND High normal levels of thyroid-stimulating hormone (TSH) have been reported to be associated with chronic kidney disease (CKD) among euthyroid individuals. However, there has been only limited research on the association between TSH and proteinuria, a major risk factor for the progression of renal disease. METHODS A cross-sectional study of 1595 euthyroid individuals was conducted. All participants were within the normal range for free triiodothyronine (T3), free thyroxine (T4), and TS...
#1Xiaodong WangH-Index: 1
#2Xinchao ZhaoH-Index: 1
Last. Xiaolei HuangH-Index: 1
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ABSTRACTBackground: The association of subclinical thyroid dysfunction (SCTD) with chronic kidney disease (CKD) among community population remains inconclusive. Our aim was to evaluate the associat...
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