Natural Products against Drug-Induced Cardiotoxicity

Published on Dec 1, 2017
· DOI :10.1142/9789813231160_0004
Meghana Koneru6
Estimated H-index: 6
,
Nasiruddin Nalban3
Estimated H-index: 3
+ 1 AuthorsRamakrishna Sistla1
Estimated H-index: 1
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#1Zhou WennaH-Index: 1
#2Jian OuyangH-Index: 1
Last. Honglun Wang (CAS: Chinese Academy of Sciences)H-Index: 23
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Background: Doxorubicin (Dox) is one of the most frequently prescribed anti-cancer drugs. However, clinical application with Dox is limited due to its potentially fatal cumulative cardiotoxicity. N-p-coumaroyl-4-aminobutan-1-ol (alk-A), an organic amide alkaloid and hippophamide (alk-B), a rare pyridoindole alkaloid were successfully obtained by purification and separation of seabuckthorn seed residue in our previous research. This study was undertaken to investigate the protective effect of alk...
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