PRMT5 as a druggable target for glioblastoma therapy
Abstract
In spite of standard multimodal therapy consisting of surgical resection followed by radiation and concurrent chemotherapy, prognosis for glioblastoma (GBM) patients remains poor. The identification of both differentiated and undifferentiated “stem cell like” populations in the tumor highlights the significance of finding novel targets that affect the heterogeneous tumor cell population. Protein arginine methyltransferase 5 (PRMT5) is one such...
Paper Details
Title
PRMT5 as a druggable target for glioblastoma therapy
Published Date
Nov 2, 2017
Journal
Volume
20
Issue
6
Pages
753 - 763
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Notes
History