Development of an Ultra High Resolution PET Scanner for Imaging Rodent Paws: PawPET

Published on Jan 1, 2018in IEEE Transactions on Radiation and Plasma Medical Sciences
· DOI :10.1109/TRPMS.2017.2765486
Felipe Godinez5
Estimated H-index: 5
('KCL': King's College London),
Kuang Gong15
Estimated H-index: 15
(UC Davis: University of California, Davis)
+ 3 AuthorsRamsey D. Badawi29
Estimated H-index: 29
(UC Davis: University of California, Davis)
Sources
Abstract
A positron emission tomography (PET) scanner with submillimeter spatial resolution, capable of in vivo imaging of murine extremities was built based on two dual ended readout, hybrid depth of interaction (DOI) PET detectors. Each was composed of a 36 {\times } \,\, 36 array of 0.43 mm {\times } \,\, 0.43 mm {\times } \,\, 8 mm unpolished lutetium oxyorthosilicate crystals separated by a 50~\boldsymbol \mu \text{m} white diffuse reflector. The array was coupled to a position-sensing photomultiplier tube at one end and to an avalanche photodiode at the other end. The detector characterization included crystal identification accuracy, DOI, energy, and timing resolution measurements. The scanner was characterized in terms of its spatial resolution and its sensitivity and mouse images were acquired of a mouse paw injected with 18-F-NaF. Out of the 36 {\times } \,\, 36 crystals only 33 {\times } \,\, 33 crystals were identified. The coincidence timing, DOI, and energy resolution of the scanner was measured to be 2.8 ns, 1.4 mm, and 27%, respectively. The scanner’s spatial resolution was measured with a line source and determined from an ordered subsets expectation maximization reconstruction to be 0.56 mm. The sensitivity of the scanner was measured to be 0.6% at the center of the field of view.
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#1Hui ZhangH-Index: 63
#2Ruhong ZhouH-Index: 76
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Depth of interaction (DOI) technology can improve the spatial resolution of nuclear medicine imaging system which uses scintillation detectors such as Positron Emission Tomography (PET). In this paper, a prototype detector module with DOI capability is established to make complementary characteristic tests on an existing method and to improve the experimental performance using the same method. We investigate the gamma incident surface and incident angle effects on the positioning method with our...
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#2Anupam Mitra (UC Davis: University of California, Davis)H-Index: 15
Last. Siba P. Raychaudhuri (UC Davis: University of California, Davis)H-Index: 50
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Aim To quantify the progression and severity of mouse collagen-induced arthritis (CIA) using an in vivo imaging tool, 18F-fluorodeoxyglucose (18F-FDG) PET/CT and validate it against gold standard ‘histopathological’ evaluation. Method The PET radiotracer 18F-FDG, a marker for glucose metabolism, was injected in mice at different stages of CIA and the radiotracer distribution was imaged using a PET scanner. A sequential CT scan provided correlated anatomy. Radiotracer concentration was derived fr...
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#1Yang Yongfeng (UC Davis: University of California, Davis)H-Index: 22
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UNLABELLED: We developed a prototype small-animal PET scanner based on depth-encoding detectors using dual-ended readout of small scintillator elements to produce high and uniform spatial resolution suitable for imaging the mouse brain. METHODS: The scanner consists of 16 tapered dual-ended-readout detectors arranged in a 61-mm-diameter ring. The axial field of view (FOV) is 7 mm, and the transaxial FOV is 30 mm. The scintillator arrays consist of 14 × 14 lutetium oxyorthosilicate elements, with...
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#2Simon R. CherryH-Index: 92
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Spatial resolution is an important metric for performance characterization in PET systems. Measuring spatial resolution is straightforward with a linear reconstruction algorithm, such as filtered backprojection, and can be performed by reconstructing a point source scan and calculating the full-width-at-half-maximum (FWHM) along the principal directions. With the widespread adoption of iterative reconstruction methods, it is desirable to quantify the spatial resolution using an iterative reconst...
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