Abstract A23: Daurinol suppresses human cancer metastasis by inhibition of focal adhesion kinase (FAK) signaling pathways

Background and Purpose: Globally most of the cancers associated with mortality and morbidity arise from metastatic spread of primary tumors. Traditional anti-cancer drugs mostly focus on inhibiting tumor cell growth or killing tumor cells directly or indirectly; however, there are only a few drugs that specifically inhibit metastasis of tumor cells. Noteworthy, the focal adhesive kinase (FAK) plays an important role in cytoskeleton remodeling...