The cytotoxic effects of dimethyl sulfoxide in mouse preimplantation embryos: a mechanistic study
Abstract
Rationale: Dimethyl sulfoxide (DMSO) is commonly used as a solvent for water-insoluble substances, a vehicle for drug therapy, and a cryoprotectant for cultured cells. DMSO induced embryonic defects and its mechanism of action remains unclear. The rationale is based on the assumption that DMSO supplementation should induce long-term negative effects on both pre- and post-implantation embryo development. Methods: DMSO induced oxidative stress, ER...
Paper Details
Title
The cytotoxic effects of dimethyl sulfoxide in mouse preimplantation embryos: a mechanistic study
Published Date
Jan 1, 2017
Journal
Volume
7
Issue
19
Pages
4735 - 4752
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