Naringenin as a novel inhibitor of Two-Pore Channel 2 controlling the angiogenic process in vitro and in vivo

Volume: 122, Issue: 1, Pages: 161
Published: Jan 1, 2017
Abstract
Two Pore Channels (TPCs) are an emerging family of intracellular channels, expressed on acidic compartments, which mediate calcium signaling evoked by NAADP. In particular, we demonstrated that TPC2 isoform has a main role in angiogenesis (Favia et al. PNAS 2014 Nov 4;111(44):E4706-15). TPC2 inhibition is emerging as a key therapeutic step in a range of important pathological conditions including the progression and metastatic potential of...
Paper Details
Title
Naringenin as a novel inhibitor of Two-Pore Channel 2 controlling the angiogenic process in vitro and in vivo
Published Date
Jan 1, 2017
Volume
122
Issue
1
Pages
161
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