CaMKKbeta/AMPK Negatively Regulates Adiposity - eScholarship
Published: Jan 1, 2011
Abstract
Lipid synthesis and storage in adipose tissues contribute to energy homeostasis, which is inversely regulated by activated AMP-activated protein kinase (AMPK). Here, I report that Ca2+/calmodulin-dependent protein kinase kinase beta (CaMKKbeta) negatively regulates lipogenesis in adipocytes through its phosphorylation of AMPK. Specifically, the glucagon-activated CaMKKbeta/AMPK cascade inhibits acetyl-CoA carboxylase (ACC) activity through the...
Paper Details
Title
CaMKKbeta/AMPK Negatively Regulates Adiposity - eScholarship
Published Date
Jan 1, 2011
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