ADAM10-mediated ephrin-B2 shedding promotes myofibroblast activation and organ fibrosis
Abstract
Maladaptive wound healing responses to chronic tissue injury result in organ fibrosis. Fibrosis, which entails excessive extracellular matrix (ECM) deposition and tissue remodeling by activated myofibroblasts, leads to loss of proper tissue architecture and organ function; however, the molecular mediators of myofibroblast activation have yet to be fully identified. Here we identify soluble ephrin-B2 (sEphrin-B2) as a new profibrotic mediator in...
Paper Details
Title
ADAM10-mediated ephrin-B2 shedding promotes myofibroblast activation and organ fibrosis
Published Date
Oct 23, 2017
Journal
Volume
23
Issue
12
Pages
1405 - 1415
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