[P4-237]: WHITE MATTER MICROSTRUCTURAL AND EXTRACELLULAR FREE-WATER CHANGES ASSOCIATED WITH COGNITION IN AMNESTIC MILD COGNITIVE IMPAIRMENT AND ALZHEIMER'S DISEASE

Alzheimer's Disease (AD) and amnestic Mild Cognitive Impairment (aMCI) are associated with white matter (WM) microstructure abnormalities revealed by diffusion tensor imaging (DTI) methods (Acosta-Cabronero et al., 2010). However, the current DTI model suffers from partial volume effects, therefore preventing accurate quantification of WM abnormalities and their roles in cognitive deficits in the prodromal and clinical stages of AD...