Lactate Metabolism in Human Lung Tumors
Abstract
Cancer cells consume glucose and secrete lactate in culture. It is unknown whether lactate contributes to energy metabolism in living tumors. We previously reported that human non-small-cell lung cancers (NSCLCs) oxidize glucose in the tricarboxylic acid (TCA) cycle. Here, we show that lactate is also a TCA cycle carbon source for NSCLC. In human NSCLC, evidence of lactate utilization was most apparent in tumors with high 18fluorodeoxyglucose...
Paper Details
Title
Lactate Metabolism in Human Lung Tumors
Published Date
Oct 1, 2017
Journal
Volume
171
Issue
2
Pages
358 - 371.e9
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