Iron‐catalyzed C(5)−H Imidation of Azole with N‐Fluorobenzenesulfonimide

Published on Dec 19, 2017in Advanced Synthesis & Catalysis5.851
· DOI :10.1002/ADSC.201701124
Xiaojiao Wang5
Estimated H-index: 5
(Sichuan University),
Bowen Lei6
Estimated H-index: 6
(Sichuan University)
+ 4 AuthorsZiyuan Li11
Estimated H-index: 11
(Sichuan University)
An iron(II)-catalyzed direct imidation of oxazole and thiazole with N-fluorobenzenesulfonimide (NFSI) through C(5)−H bond cleavage is disclosed, providing C5-imidated azoles in moderate to excellent yields with broad substrate scope. This reaction represents the first iron-catalyzed C−H imidation of arene where NFSI serves as the imidation reagent, and potentially constitutes an efficient access to C5-functionalized azole with great medicinal significance.
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