EGFR heterogeneity and implications for therapeutic intervention in glioblastoma
Abstract
Patients with glioblastoma (GBM) have a universally poor prognosis and are in urgent need of effective treatment strategies. Recent advances in sequencing techniques unraveled the complete genomic landscape of GBMs and revealed profound heterogeneity of individual tumors even at the single cell level. Genomic profiling has detected epidermal growth factor receptor (EGFR) gene alterations in more than half of GBMs. Major genetic events include...
Paper Details
Title
EGFR heterogeneity and implications for therapeutic intervention in glioblastoma
Published Date
Oct 10, 2017
Journal
Volume
20
Issue
6
Pages
743 - 752
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Notes
History