Use of Probiotics in Hospitalized Adults to Prevent Clostridium difficile Infection: DownGRADE the Quality of Evidence?

We read the paper by Shen et al with interest.1Shen N.T. et al.Gastroenterology. 2017; 152: 1889-1900Abstract Full Text Full Text PDF PubMed Scopus (160) Google Scholar The authors demonstrated, in a meta-analysis of randomized controlled trials (RCTs), a significant effect of probiotics in terms of preventing Clostridium difficile infection in hospitalized adults taking antibiotics. However, there are several methodologic flaws that may escape...