Analysis of SNP-SNP interactions and bone quantitative ultrasound parameter in early adulthood

Osteoporosis individual susceptibility is determined by the interaction of multiple genetic variants and environmental factors. The aim of this study was to conduct SNP-SNP interaction analyses in candidate genes influencing heel quantitative ultrasound (QUS) parameter in early adulthood to identify novel insights into the mechanism of disease. The study population included 575 healthy subjects (mean age 20.41; SD 2.36). To assess bone mass QUS...