The percutaneous toxicokinetics of VX in a damaged skin porcine model and the evaluation of WoundStat™ as a topical decontaminant

This study used a damaged skin, porcine model to evaluate the in vivo efficacy of WoundStat™ for the decontamination of superficial, nerve agent‐contaminated wounds. Anaesthetized animals were randomly assigned to either control ( n = 7), no decontamination ( n = 12) or WoundStat™ ( n = 12) treatment groups. Pigs were exposed to a 5× LD 50 dose of neat, radiolabelled S ‐[2‐(diisopropylamino)ethyl]‐ O ‐ethyl methyl‐phosphonothioate (VX; or...