Arginine methylation catalyzed by PRMT1 is required for B cell activation and differentiation
Abstract
Arginine methylation catalyzed by protein arginine methyltransferases (PRMT) is a common post-translational modification in mammalian cells, regulating many important functions including cell signalling, proliferation and differentiation. Here we show the role of PRMT1 in B-cell activation and differentiation. PRMT1 expression and activity in human and mouse peripheral B cells increases in response to in vitro or in vivo activation. Deletion of...
Paper Details
Title
Arginine methylation catalyzed by PRMT1 is required for B cell activation and differentiation
Published Date
Oct 12, 2017
Journal
Volume
8
Issue
1
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