Task-evoked pupil dilation and BOLD variance as indicators of locus coeruleus dysfunction
Abstract
Pupillary responses during cognitive tasks are linked to functioning of the locus coeruleus (LC). The LC is an early site of abnormal tau deposition, which may contribute to key aspects of Alzheimer's disease (AD) pathophysiology. We previously found attenuation of pupillary responses to increases in cognitive load in individuals with mild cognitive impairment (MCI), suggesting pupillary responses may provide a biomarker of early risk for AD...
Paper Details
Title
Task-evoked pupil dilation and BOLD variance as indicators of locus coeruleus dysfunction
Published Date
Dec 1, 2017
Journal
Volume
97
Pages
60 - 69
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