Cross-activating c-Met/β1 integrin complex drives metastasis and invasive resistance in cancer.
Volume: 114, Issue: 41, Pages: 201701821
Published: Oct 10, 2017
Abstract
The molecular underpinnings of invasion, a hallmark of cancer, have been defined in terms of individual mediators but crucial interactions between these mediators remain undefined. In xenograft models and patient specimens, we identified a c-Met/β1 integrin complex that formed during significant invasive oncologic processes: breast cancer metastases and glioblastoma invasive resistance to antiangiogenic VEGF neutralizing antibody, bevacizumab....
Paper Details
Title
Cross-activating c-Met/β1 integrin complex drives metastasis and invasive resistance in cancer.
Published Date
Oct 10, 2017
Volume
114
Issue
41
Pages
201701821
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