Abstract 1406: Towards an RNA expression-based signature for oncogene-induced replication stress

Introduction Certain tumor subgroups, including triple negative breast cancers (TNBCs), are characterized by high levels of genomic instability (GI). These tumors are typically very aggressive and difficult to threat. Increasingly, we realize that GI is fueled by replication stress (RS). RS can be induced by expression of oncogenes, including CCNE1, MYC and CDC25A, which perturb initiation, elongation and/or termination phases of DNA...