Augmentation of Antitumor Immunity by Human and Mouse CAR T Cells Secreting IL-18
Abstract
The effects of transgenically encoded human and mouse IL-18 on T cell proliferation and its application in boosting chimeric antigen receptor (CAR) T cells are presented. Robust enhancement of proliferation of IL-18-secreting human T cells occurred in a xenograft model, and this was dependent on TCR and IL-18R signaling. IL-18 augmented IFN-γ secretion and proliferation of T cells activated by the endogenous TCR. TCR-deficient, human...
Paper Details
Title
Augmentation of Antitumor Immunity by Human and Mouse CAR T Cells Secreting IL-18
Published Date
Sep 1, 2017
Journal
Volume
20
Issue
13
Pages
3025 - 3033
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