Impact of magnetic susceptibility anisotropy at 3 T and 7 T on T2*-based myelin water fraction imaging

Myelin Water Fraction (MWF) mapping can be achieved by fitting multi-gradient recalled echo (MGRE) magnitude images with a three-component model or a pseudo-continuous T2∗ distribution. Recent findings of compartment-specific orientation-dependent magnetic susceptibility shifts have spurred the inclusion of frequency offset (Δf) terms in the fitting models. In this work, we performed simulations to assess the impact of Δf's on the MWF, derived...