Development and study of 99m Tc-1-Thio-D-glucose for visualization of malignant tumors

Published on Sep 28, 2017
· DOI :10.1063/1.5001662
R. Zeltchan3
Estimated H-index: 3
A. A. Medvedeva2
Estimated H-index: 2
+ 6 AuthorsViktor Sergeyevich Skuridin1
Estimated H-index: 1
The preclinical studies of 99mTc-1-Thio-D-glucose, a new tumor-seeking agent based on technetium-99m-labeled glucose derivative, were conducted, and the feasibility of using this radiopharmaceutical for tumor visualization was studied. The preclinical studies were carried out strictly in accordance with the local legislation and were regulated by the generally accepted research standards. 99mTc-1-Thio-D-glucose was found to have optimal pharmacokinetic and physico-chemical properties for diagnostic imaging and was proved to belong to the low-toxic substances. The potential utility of 99mTc-1-thio-D-glucose for tumor imaging was studied in vitro and in vivo models. The present study demonstrated that 99mTc-1-Thio-D-glucose is a prospective radiopharmaceutical for cancer visualization.
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9 Authors (E. S. Stasyuk, ..., Roman Zelchan)
#1R. Zeltchan (Tomsk Polytechnic University)H-Index: 3
#2A. A. Medvedeva (Tomsk Polytechnic University)H-Index: 5
Last. A. DergilevH-Index: 2
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Purpose: to study the potential utility of 1-thio-D-glucose labeled with 99mTc for cancer imaging in laboratory animals. Materials and method: the study was carried out in cell cultures of normal CHO (Chinese hamster ovary cells CHO) and malignant tissues MCF-7 (human breast adenocarcinoma MCF-7). To evaluate the uptake of 99mTc-1-thio-D-glucose in normal and tumor tissue cells, 25 MBq of 1-thio-D-glucose labeled with 99mTc was added to the vials with 3 million cells and incubated for 30 minutes...
Cited By2
#1V. Chernov (Research Medical Center)H-Index: 2
#2A. Medvedeva (Research Medical Center)H-Index: 2
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