Parkin-Independent Mitophagy Controls Chemotherapeutic Response in Cancer Cells
Abstract
Mitophagy is an evolutionarily conserved process that selectively targets impaired mitochondria for degradation. Defects in mitophagy are often associated with diverse pathologies, including cancer. Because the main known regulators of mitophagy are frequently inactivated in cancer cells, the mechanisms that regulate mitophagy in cancer cells are not fully understood. Here, we identified an E3 ubiquitin ligase (ARIH1/HHARI) that triggers...
Paper Details
Title
Parkin-Independent Mitophagy Controls Chemotherapeutic Response in Cancer Cells
Published Date
Sep 1, 2017
Journal
Volume
20
Issue
12
Pages
2846 - 2859
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