THU0538 Effects of glucocorticoids and methotrexate-based therapeutic regimens on b cell subpopulations in patients with igg4-related disease

Background

IgG4-related disease (IgG4-RD) is a systemic fibro- inflammatory disorder characterized by fibrotic lesions infiltrated by IgG4 positive plasma cells (1). The prompt clinical responses obtained after B cell depletion with rituximab in IgG4-RD patients suggest that B lymphocytes drive the pathogenesis of this condition and sustain disease activity (2). This conclusion, however, requires further confirmation because IgG4-RD...