Dynein light chain regulates adaptive and innate B cell development by distinctive genetic mechanisms
Abstract
Mechanistic differences in the development and function of adaptive, high-affinity antibody-producing B-2 cells and innate-like, "natural" antibody-producing B-1a cells remain poorly understood. Here we show that the multi-functional dynein light chain (DYNLL1/LC8) plays important roles in the establishment of B-1a cells in the peritoneal cavity and in the ongoing development of B-2 lymphoid cells in the bone marrow of mice. Epistasis analyses...
Paper Details
Title
Dynein light chain regulates adaptive and innate B cell development by distinctive genetic mechanisms
Published Date
Sep 18, 2017
Journal
Volume
13
Issue
9
Pages
e1007010 - e1007010
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