FRI0352 Efficacy of biologics in patients with refractory takayasu arteritis and analysis of their genetic backgrounds

Background

Takayasu arteritis (TAK) is a rare disease that mostly affects young females and causes inflammation, stenosis and dilatation of the aorta and its main branches. Although glucocorticoids are effective, relapses occur frequently [1]. Recently, the efficacy of biologics has been reported in refractory TAK. HLA-B*52 is a major genetic risk factor and associated with the severity [2]. Our group reported a SNP in the regions of...