AB0170 Diminished peripheral t-cell activation along with marked th17 circulating profile in ssc

Background

Systemic sclerosis (SSc) is a rare, debilitating connective tissue disease characterized by immunological alterations, vasculopathy and progressive skin and multiorgan fibrosis. The autoimmune dysregulation in SSc comprises lymphocyte activation that leads to autoantibody production, abnormal production of cytokines and chemokines, and impairment of the innate immunity. Recent research has shown that the T cell activation and...