Role of subchondral bone properties and changes in development of load-induced osteoarthritis in mice

Animal models recapitulating post-traumatic osteoarthritis (OA) suggest that subchondral bone (SCB) properties and remodeling may play major roles in disease initiation and progression. Thus, we investigated the role of SCB properties and its effects on load-induced OA progression by applying a tibial loading model on two distinct mouse strains treated with alendronate (ALN).Cyclic compression was applied to the left tibia of 26-week-old male...