New indole-based chalconoids as tubulin-targeting antiproliferative agents
Abstract
Tubulin-targeting compounds have a broad anticancer spectrum and are an important class of chemotherapeutic agents. Due to the importance of 3-bromo-3,5-dimethoxyphenyl scaffold in the anticancer activity of microtubule inhibitors such as crolibulin (EPC2407), we introduced this functionality into the indole-derived chalcones. Thus, we describe here the synthesis and biological evaluation of new indole-based chalconoids as tubulin-targeting...
Paper Details
Title
New indole-based chalconoids as tubulin-targeting antiproliferative agents
Published Date
Dec 1, 2017
Journal
Volume
75
Pages
86 - 98
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