Overall Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma

Published on Sep 11, 2017in The New England Journal of Medicine74.699
· DOI :10.1056/NEJMOA1709684
Jedd D. Wolchok148
Estimated H-index: 148
(Cornell University),
Vanna Chiarion-Sileni57
Estimated H-index: 57
+ 30 AuthorsJames Larkin95
Estimated H-index: 95
(University of Duisburg-Essen)
BackgroundNivolumab combined with ipilimumab resulted in longer progression-free survival and a higher objective response rate than ipilimumab alone in a phase 3 trial involving patients with advanced melanoma. We now report 3-year overall survival outcomes in this trial. MethodsWe randomly assigned, in a 1:1:1 ratio, patients with previously untreated advanced melanoma to receive nivolumab at a dose of 1 mg per kilogram of body weight plus ipilimumab at a dose of 3 mg per kilogram every 3 weeks for four doses, followed by nivolumab at a dose of 3 mg per kilogram every 2 weeks; nivolumab at a dose of 3 mg per kilogram every 2 weeks plus placebo; or ipilimumab at a dose of 3 mg per kilogram every 3 weeks for four doses plus placebo, until progression, the occurrence of unacceptable toxic effects, or withdrawal of consent. Randomization was stratified according to programmed death ligand 1 (PD-L1) status, BRAF mutation status, and metastasis stage. The two primary end points were progression-free survival a...
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