Antihypertensive drugs in stepped doses reduced stroke in elderly patients with isolated systolic hypertension

Published on Mar 9, 2020in ACP journal club
· DOI :10.7326/ACPJC-1991-115-3-065
Arthur T. Evans46
Estimated H-index: 46
(UNC: University of North Carolina at Chapel Hill)
Sources
Abstract
Source Citation SHEP Cooperative Research Group. Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hyperten...
📖 Papers frequently viewed together
1 Citations
References0
Newest
Cited By2
Newest
#1Diana Diao (UBC: University of British Columbia)H-Index: 1
#2James M Wright (UBC: University of British Columbia)H-Index: 54
Last. François Gueyffier (CNRS: Centre national de la recherche scientifique)H-Index: 40
view all 4 authors...
Background People with no previous cardiovascular events or cardiovascular disease represent a primary prevention population. The benefits and harms of treating mild hypertension in primary prevention patients are not known at present. This review examines the existing randomised controlled trial (RCT) evidence. Objectives Primary objective: To quantify the effects of antihypertensive drug therapy on mortality and morbidity in adults with mild hypertension (systolic blood pressure (BP) 140-159 m...
156 CitationsSource
#1James M Wright (UBC: University of British Columbia)H-Index: 54
#2Vijaya M Musini (UBC: University of British Columbia)H-Index: 16
Last. Rupam Gill (Manipal University)H-Index: 2
view all 3 authors...
Background Sustained elevated blood pressure, unresponsive to lifestyle measures, leads to a critically important clinical question: What class of drug to use first-line? This review answers that question. Objectives Primary objective: To quantify the benefits and harms of the major first-line anti-hypertensive drug classes: thiazides, beta-blockers, calcium channel blockers, angiotensin converting enzyme (ACE) inhibitors, alpha-blockers, and angiotensin II receptor blockers (ARB). Search method...
280 CitationsSource