Nuclear speckles: molecular organization, biological function and role in disease
Abstract
The nucleoplasm is not homogenous; it consists of many types of nuclear bodies, also known as nuclear domains or nuclear subcompartments. These self-organizing structures gather machinery involved in various nuclear activities. Nuclear speckles (NSs) or splicing speckles, also called interchromatin granule clusters, were discovered as sites for splicing factor storage and modification. Further studies on transcription and mRNA maturation and...
Paper Details
Title
Nuclear speckles: molecular organization, biological function and role in disease
Published Date
Sep 1, 2017
Journal
Volume
45
Issue
18
Pages
10350 - 10368
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