Caffeine Has a Synergistic Anticancer Effect with Cisplatin <i>via</i> Inhibiting Fanconi Anemia Group D2 Protein Monoubiquitination in Hepatocellular Carcinoma Cells
Volume: 40, Issue: 11, Pages: 2005 - 2009
Published: Jan 1, 2017
Abstract
Cisplatin is an anticancer agent and induces DNA interstrand cross-links (ICLs). ICLs activate various signaling processes and induce DNA repair pathways, including the Fanconi anemia (FA) pathway. FA complementation group D2 (FANCD2) is monoubiquitinated in response to DNA damage, leading to activation of the DNA double-strand-break repair protein, RAD51. Caffeine increases the anticancer activity of cisplatin by inhibiting DNA repair; however,...
Paper Details
Title
Caffeine Has a Synergistic Anticancer Effect with Cisplatin <i>via</i> Inhibiting Fanconi Anemia Group D2 Protein Monoubiquitination in Hepatocellular Carcinoma Cells
Published Date
Jan 1, 2017
Volume
40
Issue
11
Pages
2005 - 2009
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