Anaplastic sarcomas of the kidney are characterized by DICER1 mutations
Abstract
Anaplastic sarcoma of the kidney is a rare tumor (≤25 reported cases) characterized by the presence of cysts, and solid areas composed of bundles of undifferentiated spindle cells, showing marked cellular anaplasia (usually accompanied by TP53 overexpression). These tumors often feature prominent areas of cartilage or chondroid material. Germline mutations in DICER1, encoding the microRNA (miRNA) processor DICER1, cause an eponymous syndrome....
Paper Details
Title
Anaplastic sarcomas of the kidney are characterized by DICER1 mutations
Published Date
Jan 1, 2018
Journal
Volume
31
Issue
1
Pages
169 - 178
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