Lipoxygenase‐mediated generation of lipid peroxides enhances ferroptosis induced by erastin and RSL3
Abstract
In cancer cells the small compounds erastin and RSL3 promote a novel type of cell death called ferroptosis, which requires iron-dependent accumulation of lipid reactive oxygen species. Here we assessed the contribution of lipid peroxidation activity of lipoxygenases (LOX) to ferroptosis in oncogenic Ras-expressing cancer cells. Several 12/15-LOX inhibitors prevented cell death induced by erastin and RSL3. Furthermore, siRNA-mediated silencing of...
Paper Details
Title
Lipoxygenase‐mediated generation of lipid peroxides enhances ferroptosis induced by erastin and RSL3
Published Date
Sep 15, 2017
Journal
Volume
108
Issue
11
Pages
2187 - 2194
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