Immunohistochemistry cannot replace DNA analysis for evaluation ofBRAFV600E mutations in papillary thyroid carcinoma
Abstract
The BRAF V600E mutation is the most common genetic event occurring in papillary thyroid cancer (PTC). Recently, the possibility of using immunohistochemistry (IHC) to detect the BRAF V600E mutation has been reported.In 140 patients with classical PTC, the status of the BRAF V600E mutation was determined by IHC (using two alternative staining protocols, IHC-1 and IHC-2) and molecular biology methods: Sanger sequencing (SEQ) and real-time PCR...
Paper Details
Title
Immunohistochemistry cannot replace DNA analysis for evaluation ofBRAFV600E mutations in papillary thyroid carcinoma
Published Date
Aug 24, 2017
Journal
Volume
8
Issue
43
Pages
74897 - 74909
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