Evidence for PTGER4, PSCA and MBOAT7 as risk genes for gastric cancer on the genome and transcriptome level

Gastric carcinoma (GC) represents the fifth most common cancer type worldwide and the prognosis for affected patients remains to be poor. Effort on characterizing the somatic genomic landscape of GC revealed deep insights into the tumor biology. However, questions on interindividual differences in the risk for GC development remain to be solved. To elucidate germline risk variants and genes, GWAS in the Asian population were performed with...