SAMHD1 Promotes DNA End Resection to Facilitate DNA Repair by Homologous Recombination
Abstract
DNA double-strand break (DSB) repair by homologous recombination (HR) is initiated by CtIP/MRN-mediated DNA end resection to maintain genome integrity. SAMHD1 is a dNTP triphosphohydrolase, which restricts HIV-1 infection, and mutations are associated with Aicardi-Goutières syndrome and cancer. We show that SAMHD1 has a dNTPase-independent function in promoting DNA end resection to facilitate DSB repair by HR. SAMHD1 deficiency or Vpx-mediated...
Paper Details
Title
SAMHD1 Promotes DNA End Resection to Facilitate DNA Repair by Homologous Recombination
Published Date
Aug 1, 2017
Journal
Volume
20
Issue
8
Pages
1921 - 1935
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