Luminescence

Nanoparticle

Materials science

Optoelectronics

Magnetic nanoparticles

Photothermal therapy

Cancer

Janus

Nanotechnology

Internal medicine

Medicine

Cancer therapy

Small

Magnetic-luminescent nanocomposites have multiple uses including multimodal imaging, magnetic targeted drug delivery, and cancer imaging-guided therapies. In this work, dumbbell-like MnFe2 O4 -NaYF4 Janus nanoparticles are synthesized via a two-step thermolysis approach. These synthesized nanoparticles exhibit stability in aqueous solutions and very low cytotoxicity after poly(acryl amide) modification. High cellular uptake efficiency is observed for the folic acid-conjugated MnFe2 O4 -NaYF4 in human esophagus carcinoma cells (Eca-109) due to the upconversion luminescence properties as well as the folate targeting potential. The MnFe2 O4 -NaYF4 also strongly absorbs light in the near-infrared range and rapidly converts to heat energy. It is demonstrated that Eca-109 cells incubated with MnFe2 O4 -NaYF4 are killed with high efficiency after 808 nm laser irradiation. Furthermore, the growth of tumors in mice (grown from Eca-109 cells) is highly inhibited by the photothermal effects of MnFe2 O4 -NaYF4 efficientl...

Novel Magnetic‐Luminescent Janus Nanoparticles for Cell Labeling and Tumor Photothermal Therapy