Mutant p53 stimulates cell invasion through an interaction with Rad21 in human ovarian cancer cells
Abstract
Missense mutations of TP53 are extremely common, and mutant p53 accumulation and gain-of-function play crucial roles in human ovarian cancer. Here, we investigated the role of mutant p53 in cell migration and invasion as well as its underlying molecular mechanisms in human ovarian cancer cells. Overexpression of mutant p53 significantly increased migration and invasion in p53-null SKOV3 cells. In contrast, knockdown of mutant p53 significantly...
Paper Details
Title
Mutant p53 stimulates cell invasion through an interaction with Rad21 in human ovarian cancer cells
Published Date
Aug 22, 2017
Journal
Volume
7
Issue
1
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